CD8A and neoplasm: CD27-mediated T cell depletion resulted in increased ratios of CD8-T or CD4-Th cells to Treg, more CD8-T cells displaying the phenotype of central memory (CD127+CD44+CD62L+), and higher levels of proliferation (Ki-67+), activation (IFNγ+, TNFα+, IL-2+), and cytolysis (GzmB+) in lymphoid organs and tumor infiltrates [16].