The interaction with SPAG6 was particularly intriguing due to a number of phenotypic and functional similarities to CCDC103: mouse Spag6 mutants display ciliary defects and many phenotypic hallmarks of PCD (Sapiro et al., 2002); Spag6 can promote effective migration of cortical neurons and proliferation and migration of mouse embryonic fibroblasts (Sapiro et al., 2002; Li et al., 2015; Alciaturi et al., 2019); Spag6 has increased expression in myeloid leukemia lines (Cooley et al., 2016; Yang et al., 2015; Yin et al., 2018); and Spag6 can promote microtubule stability (Zheng et al., 2019). Here, SPAG6 is linked to myeloid leukemia.