Secondary outcomes did not change during follow-up for CAN (autonomic symptoms profile), with a baseline of 17.9 (9.8) and at 3 years 17.3 (10.3) (P = 0.63, n = 81) or for kidney disease as measured by albumin to creatinine ratio (ACR, unit = mg/g), log(ACR), with a baseline of 3.96 (1.68) and at 3 years 4.13 (1.94) (P = 0.21, n = 83). Here, ALB is linked to Crouzon syndrome-acanthosis nigricans syndrome.