Given that brain samples from patients with AD and transgenic rodent models display higher levels of phosphorylated JNK, ERK, and p38 (66–68), and cardiac transcriptomic data from patients with HFpEF display enhanced MAPK signaling as well as an enrichment in gene networks associated with AD (69), it is conceivable that MAPK pathway activation contributes to the cardiogenic dementia profile. Here, MAPK8 is linked to dementia.