For example, lncRNA MIAT was reported to promote proliferation and invasion of HCC cells via sponging miR-214 [21]; up-regulation of lncRNA SNHG16 inhibited HCC cell proliferation and chemotherapy resistance via functionally sponging hsa-miR-93 [22] and lncRNA HULC can trigger autophagy by stabilizing Sirt1 and attenuate the sensitivity of HCC cells to chemotherapeutic agents [23]. The gene discussed is SIRT1; the disease is hepatocellular carcinoma.