CD244 and viral infectious disease: These potential mechanisms include NF-kB-mediated immune response (i.e. PIDD1) (Bock et al., 2013; Tinel et al., 2007), immune synaptic interaction involved in T cell activation (i.e. CD151) (Rocha-Perugini et al., 2014) and T cell exhaustion in viral infection (i.e. CD244) (Agresta et al., 2018; Pacheco et al., 2013).