EMT transcription factors (EMT-TF), including the SNAIL, TWIST, and ZEBfamilies, as well as c-Fos and Fra-1 promote the acquisition of a mesenchymal phenotype.EMT-TFs regulate cell plasticity and are involved in many stages of cancer progression suchas initiation, primary growth, invasion, dissemination, metastasis, and drug resistance[43-45]. This evidence concerns the gene TF and cancer.