Many common transcription factors have been found including SP-1, RELA, NF-κB, STAT3, HIF-1α, PPARγ, c-FOS, and c-JUN (Figure 3D) and together with a review of the literature, the transcription factors network in HF and comorbidities are briefly summarized as follows: (1) Regulation of inflammation. This evidence concerns the gene NFKB1 and hydrops fetalis.