Another example is the m.8993T > G mutation associated with maternally inherited Leigh syndrome (subacute necrotizing encephalopathy) and NARP (neuropathy, ataxia, and pigmentary retinopathy) that affects the ATPase6 subunit (complex V) by changing a hydrophobic leucine to an arginine. The gene discussed is NPTX2; the disease is Leigh syndrome.