The potential anti-tumor effect of oxidative stress is confirmed by the notion that nuclear factor-erythroid 2-related factor 2 (NRF2), a prominent transcriptional inducer of cellular antioxidant response, was shown to be protective for cancer cells through modulation of apoptosis and increased chemoresistance (Kahroba et al., 2019). This evidence concerns the gene NFE2L2 and neoplasm.