The importance of WRAP53 for telomerase-mediated telomere maintenance is underscored by the fact that mutations in the WRAP53 gene cause the two related telomeropathies, dyskeratosis congenita and Hoyeraal–Hreidarsson syndrome (Batista et al., 2011; Zhong et al., 2011; Bergstrand et al., 2020). The gene discussed is WRAP53; the disease is dyskeratosis congenita.