TDP-43 (TAR DNA-binding protein 43), another hnRNP, which, similar to FUS, is heavily implicated in the etiopathology of several neurodegenerative diseases including ALS and Alzheimer’s disease (Gao et al., 2018), also plays an important role in NHEJ-mediated DSB repair (Mitra et al., 2019). Here, FUS is linked to neurodegenerative disease.