PI3Kγ-specific inhibition is also shown to polarize the myeloid cells to the more immune-stimulatory M1-like phenotype from the immunosuppressive M2-like phenotype in tumor models including 4T1 breast cancer, which correlates with higher CD8/Treg ratio from increased CD8+ T-cell infiltration (De Henau et al., 2016; Kaneda et al., 2016). This evidence concerns the gene CD8A and breast carcinoma.