PIK3CA and neoplasm: However, phase I/II clinical trials for dual PI3K/mTOR inhibitors dactolisib (BEZ235), apitolisib (GDC-0980), and gedatolisib (PF-05212384) showed a relatively poor safety profile that results in low tolerable dosage and modest anti-tumor responses (Dolly et al., 2016; Wainberg et al., 2017; Wise-Draper et al., 2017).