S1P receptors, S1PR1 is amongst the most abundant subtype of S1P receptors in the brain, which plays a crucial role in sustaining hallmark endothelial functions and could be as a regulator for microglial activation following cerebral ischemia (Moon et al., 2015; Nitzsche et al., 2021). The gene discussed is S1PR1; the disease is Cerebral ischemia.