Because an increased expression of TLR4 in CRC is common and TLR4/MyD88 signaling is associated with poor prognosis (Wang et al., 2010; Kantola et al., 2012; Tye and Jenkins, 2013), we analyzed TLR4 expression in colorectal adenocarcinoma specimen according to MMR status. Here, MYD88 is linked to colorectal adenocarcinoma.