There were significant positive correlations between TLR4 and MMR genes (MSH2, MSH6, MLH1, and PMS2) in TCGA COAD dataset (Figure 3A), but MSH2, MSH6, and PMS2 positive correlations were not confirmed in TCGA PanCancer Atlas colon adenocarcinoma dataset (Figure 3B). The gene discussed is MSH2; the disease is colon adenocarcinoma.