TNFRSF11A and osteoporosis: The three of them maintain a certain balance until diseases such as osteoporosis occurs and inhibiting the RANKL/RANK pathway to inhibit osteoclast has been proven to be effective, which can also be reversely verified for the OPG knockout mice have osteoporosis (Mizuno et al., 1998; Nakashima and Takayanagi, 2011; Bae et al., 2017).