ME/CFS or fibromyalgia:- Suppress cortisol levels to reactivate ACTH secretion (modeled) (184) - Blocking of central glucocorticoids receptors (GRs) (modeled) (185)- Inhibition of Th1 cytokines followed by inhibition of GRs (modeled for Gulf War Illness) (186). The gene discussed is POMC; the disease is fibromyalgia.