However, it did not improve fibromyalgia symptoms (204)—this appears consistent with van den Berghe et al.'s findings described above, whereby the metabolic effects of GH only occur in combination with adequate thyroid hormone function. Others have administered GHRH and arginine to fibromyalgia patients—not in order to assess therapeutic potential, but in order to evaluate HPS-axis dysfunction (100). This evidence concerns the gene GH1 and fibromyalgia.