As one of target genes regulated by miR-139-3p, ISG20L2 has recently been related to hepatocellular carcinoma prognosis (Zhu et al., 2019), consistent with an immunogenomic landscape study which adds the roles of ISG20L2 in reflecting levels of infiltration in diverse immune cells (Xiao et al., 2021). This evidence concerns the gene ISG20L2 and hepatocellular carcinoma.