Increased expression levels of DAP3 have been observed in invasive glioblastoma as well as glioma cells with induced migratory phenotype (Mariani et al., 2001), while an inverse association between DAP3 expression and clinical outcome has been found in breast cancer, corresponding to the pro-apoptotic function of DAP3 (Wazir et al., 2012). This evidence concerns the gene DAP3 and central nervous system cancer.