For instance, hypoxia induced the expression of IL-17 in FOXP3+ Tregs in colorectal cáncer (CRC), FOXP3+IL-17+ T cells were then capable of inducing CRC-associated cell markers in bone marrow-derived mononuclear cells and drove the cells to be cancer-initiating cells (Yang et al., 2011). The gene discussed is IL17A; the disease is cancer.