While plentiful excellent reviews on Wnt signaling in human diseases, particularly the kidney disorders, have been published (Clevers and Nusse, 2012; Zhou and Liu, 2015; Zuo and Liu, 2018), relatively less is reported on the regulation and divergent functions of LRP5 and LRP6 (Joiner et al., 2013). Here, LRP5 is linked to kidney disorder.