LRP5 and type 2 diabetes mellitus: Recent studies have shown that the expression of LRP5 is upregulated in renal tubules of type 1 and type 2 diabetes and unilateral ureteral obstruction (UUO) models, and knockout of LRP5 in the kidney of UUO model down-regulates TGF-β/Smad signaling and ameliorates tubulointerstitial fibrosis without changing the Wnt/β-catenin signaling (He et al., 2020).