The existing evidence had clearly shown that Pyk2 modulates mitochondrial calcium uptake through phosphorylation of the MCU in cardiomyocyte (O-Uchi et al., 2014), and the Pyk2/MCU pathway is activated in a rat cerebral ischemia model, which is responsible for mitochondrial dysfunction and neuronal apoptosis (Zhang et al., 2018). The gene discussed is PTK2B; the disease is brain ischemia.