In the endothelial cells, Ang II binds to EC receptors and facilitates the expression of plasminogen activator inhibitor-1 and cell adhesion molecules, which may promote the development of atherosclerosis and myocardial infarction (Luscinskas and Gimbrone, 1996; St Paul et al., 2020), due to promoting ROS generation, increasing the cell-surface expression of cell adhesion molecules, and enhancing leukocyte adhesiveness to ECs, eventually causing endothelium dysfunction. This evidence concerns the gene AGT and atherosclerosis.