Consistent with our in vitro findings, CORO6 depletion by two independent shRNAs led to a significant suppression of ccRCC tumor growth monitored by tumor size (Figure 9A), growth curve (Figure 9B), and tumor weight (Figure 9C), suggesting that CORO6 indeed acted as a tumor-promoting factor in the development of ccRCC. Here, CORO6 is linked to nonpapillary renal cell carcinoma.