Furthermore, a second xenograft mouse model validated that CORO6 significantly promoted ccRCC tumor growth (Figures 9F–H) attenuated by WNT signaling inhibitor IWP-O1 (Figures 9F–H), suggesting the involvement of WNT signaling in CORO6-mediated ccRCC growth in vivo. Here, CORO6 is linked to nonpapillary renal cell carcinoma.