High apo-CIII levels are associated with hypertriglyceridemia (Kohan, 2015; Dai et al., 2019; Taskinen et al., 2019) and increased cardiovascular disease risk in the general population (Wyler Von Ballmoos et al., 2015; Rosenson et al., 2016; Dai et al., 2019) and diabetes mellitus (Juntti-Berggren and Berggren, 2017; Christopoulou et al., 2019). The gene discussed is APOC3; the disease is cardiovascular disorder.