Blocking the IL-1 pathway genetically using either Il1β−/−, Il1r1−/−, or Nlrp3−/− mice, or treating WT mice with either IL-1α- or IL-1β-neutralizing antibodies or IL-1 receptor antagonist, anakinra, significantly reduces vasculitis in the Lactobacillus casei cell wall extract (LCWE)-induced KD model (24–26). The gene discussed is IL1A; the disease is vasculitis.