Although miR-223 has been reported to negatively control NLRP3 activation (42), it is also possible that miR-223 targets other proteins involved in inflammatory immune responses that may potentially contribute to LCWE-induced KD vasculitis, such as CXCL2, CCL3 (52), STAT3, and IL-6 (60). The gene discussed is STAT3; the disease is vasculitis.