To explore the immunomodulatory activities of DLP4, a mouse abscess model was established, as the healing of skin abscess is a complex, coordinated and orderly process to promote tissue repair and regenerate, there are a variety of cells and cytokines participate in the process (Rousselle et al., 2018; Hou et al., 2020). This evidence concerns the gene DLGAP4 and Cutaneous abscess.