DSG1 and skin disorder: Besides, like exfoliative toxins (ETs), Exh can specifically recognize and digest desmoglein 1 (Dsg1) (Fudaba et al., 2005; Nishifuji et al., 2005), causing the separation of cells in the upper stratum spinosum, forming typical symptoms of dermatitis, these symptoms all indicated that they have similar pathophysiological functions in animals and human (Hanakawa et al., 2002; Nishifuji et al., 2008; Mariutti et al., 2015).