HIF-1α is also correlated to mTOR signaling, frequently aberrant in ALL models: coculture of ALL with stromal cells in hypoxic condition was able to induce HIF-1α and AKT/mTOR networks, and mTOR inhibition decreased HIF-1α, inducing ALL cell chemosensitization (91). This evidence concerns the gene AKT1 and acute lymphoblastic leukemia.