NOTCH1 and B-cell chronic lymphocytic leukemia: Gain-of-function mutations as well as non-mutational hyperactivation of NOTCH1 and NOTCH2 have been described in B-cell specific lymphoproliferative disorders, including Chronic Lymphocytic Leukemia (CLL) and different Non-Hodgkin lymphoma subtypes (i.e., Diffuse Large B cell lymphomas, Mantle Cell lymphoma, Burkitt’s lymphoma) (67).