It has also been shown that C-C Motif Chemokine Ligand 2 (CCL2) and IL-8 were able to increase the adhesion of ALL cells to BM stromal cells, in a stromal-dependent manner, and to promote survival and proliferation of BM stromal cells, while they seem not to have effect on most precursor B-cell ALL survival or migration. The gene discussed is CCL2; the disease is acute lymphoblastic leukemia.