Quercetin and AKT formed the highest number of hydrogen bonds, and all the binding sites of quercetin and diosgenin with PI3K were on the ASP1017 residue, indicating that quercetin and diosgenin were the two core active components of STF and that the effect of STF in treating GC and reversing MDR might be mediated by the PI3K/AKT signaling pathway. The gene discussed is AKT1; the disease is gastric cancer.