CD274 and neoplasm: In recent years, multidisciplinary approaches have significantly increased the quest for an even more accurate molecular classification through the assessment of the mutational status in multiple oncogenes and tumor suppressor genes; in the immuno-oncological field, such efforts have already produced some approved tests (PD-L1 expression and microsatellite instability rates) and other advanced tests yet to be fully proven for efficacy (tumor mutation load, neoantigen pattern, intratumor T-cell infiltration rate) (5, 8–10).