CD68 and neoplasm: From Figure 3D, we also found tumor necrosis were more likely to present in ccRCC with increased CD68+ or CD163+ TAMs (OR: 2.47, 95% CI 1.39–4.37, I2 = 46.0%, p = 0.157; OR: 4.82, 95% CI 1.33–17.51, I2 = 0.0%, p = 0.453, respectively).