AOC1 and neoplasm: In multivariate Cox regression hazard analysis, tumor depth, Stages‐III/IV and high AOC1 expression were associated with poor prognosis in DFS (HR = 2.042, 95% CI =  1.200–3.475, p =  0.008; HR = 1.793, 95% CI =  1.068-3.010, p =  0.027; HR =  18.842, 95% CI =  7.459–47.597, p < 0.001), and tumor depth and high AOC1 expression was a significant contributing factor for poor prognosis in OS (HR = 1.946, 95% CI =  1.143-3.314, p =  0.014; HR = 19.343, 95% CI =  7.649–48.920, p < 0.001) (Table 3).