Here, we first declared that MRPL15 was up-regulated in tumor tissues in patients with NSCLC via multiple cohorts including GEPIA, ONCOMINE and eight GEO series (GSE8569, GSE101929, GSE33532, GSE27262, GSE21933, GSE19804, GSE19188, GSE18842). The gene discussed is MRPL15; the disease is neoplasm.