Here, we first declared that MRPL15 was up-regulated in tumor tissues in patients with NSCLC via multiple cohorts including GEPIA, ONCOMINE and eight GEO series (GSE8569, GSE101929, GSE33532, GSE27262, GSE21933, GSE19804, GSE19188, GSE18842). Here, MRPL15 is linked to non-small cell lung carcinoma.