CD274 and neoplasm: Moreover, in the tumor stage analysis, the PD-L1 expression score in patients with stage IV disease was considerably higher than that in those with stage I, II or III disease (5.8 ± 1.9 vs. 2.0 ± 1.6, P <0.001, vs. 3.1 ± 2.2, P < 0.01, vs. 3.2 ± 1.8, P <0.05, respectively), (Figure 6C).