CD4 and neoplasm: Notably, our results showed that despite the high frequency of IFN-γ+CD4+ T cells in the tumor tissues, the frequency of IFN-γ+CD4+ T cells was not considerably different between the tumor and adjacent non-tumor tissues (26.2 ± 4.2% vs. 22.8 ± 4.8%, respectively, P > 0.05) (Figures 1A, B).