Knockdown of BST2 in HNC cell lines (HONE1, HNE1, and CNE2) sensitized their response to cisplatin and enhanced cisplatin-induced apoptosis. In total, high BST2 expression is associated with poor prognosis in 117 HNC (locally advanced nasopharyngeal carcinoma) patients with platinum-based chemotherapy. Here, BST2 is linked to nasopharyngeal carcinoma.