Overexpression of transcription factor MZF1 detected by RNA-seq (Figure 2 and Supplementary Table 1) was in line with previous reports of MZF1 association with poor clinical outcome in different tumor entities [reviewed in (88)] and especially NB tumor cell progression through modulation of tumor environment by facilitating aerobic glycolysis in NB cell lines (89). This evidence concerns the gene MZF1 and neuroblastoma.