They have been reported to participate in the progression and play a key role in the prognosis of different cancers, such as lung cancer, hepatocellular carcinoma, breast cancer, rhabdomyosarcoma, glioma, etc. BYSL is a nucleolar protein involved in the biogenesis of ribosomes through 18s rRNA processing in mammals to affect cell proliferation (50). This evidence concerns the gene BYSL and lung cancer.