Interestingly, we also found that the expression of exosomal ALIX in PC patients was higher compared with other pancreatic diseases, including PCLs (P = 0.0037), CP (P = 0.0043) and P-NET (P = 0.1132) separately, though there was no statistically significant difference between PC and P-NET (Figure 6C). Here, PDCD6IP is linked to pachyonychia congenita.