As shown in Figure 5B, among the four upregulated proteins in PC group, three were interacted with each other (ALIX, SDCBP and IST1), and the fold change of ALIX expression in PC vs. other pancreatic diseases was higher compared with both SDCBP and IST1 (Table 1). The gene discussed is PDCD6IP; the disease is pachyonychia congenita.