IRF5 and cancer: For example, YTHDF1 expression had a strong association with STAT1 in Th1 cells, STAT6 in Th2 cells, STAT3 in Th17 cells, STAT5B in Treg cells, BCL6 in Tfh cells, and IRF5 in M1 macrophages in most cancer types (Supplementary Table 5).