Among the commonly mutated genes in CRC, TP53 (53.5 vs. 79.5%, P < 0.001) and APC (46.5 vs. 75.1%, P < 0.001) displayed a significantly lower mutation rate, whereas SMAD4 (34.1 vs. 19.1%, P < 0.001), PIK3CA (28.7 vs. 19.2% P = 0.014), ACVR2A (28.7 vs. 9.1%, P < 0.001), KMT2D (22.5 vs. 6.4%, P < 0.001), LRP1 (21.7 vs. 4.8%, P < 0.001), TGFBR2 (20.2 vs. 6.4%, P < 0.001), and GRIN2A (14.7 vs. 4.5%, P < 0.001) displayed a significantly higher mutation rate in MC than in AC. The gene discussed is SMAD4; the disease is colorectal carcinoma.