Given that A549 cells expressed relatively higher levels of C3orf21 while PC-9 expressed lower levels of C3orf21, we generated C3orf21 stably silenced A549 and C3orf21 over-expressed PC-9 cells (Figures 4C, D) and these cell lines were valuable for determining the role of altered C3orf21 expression in regulating the beta-elemene-mediated anti-NSCLC effects. Here, XXYLT1 is linked to non-small cell lung carcinoma.