Saturated and trans-fatty acids in the form of HLD intake increased the expression and secretion of both IL-6 and CRP, respectively [284,285], which altered the normal metabolic homeostasis of the body and appeared to be a key factor for different diseases such as glucose intolerance, hypertension, insulin resistance, hyperlipidemia as a part of metabolic syndrome [3,286]. This evidence concerns the gene IL6 and Insulin resistance.