JAK2 and melanoma: Another experimental study on a murine model suggested that lipid-enriched diet also positively correlated with increasing adipocytes in bone marrow after injection of B16F10 melanoma cells in normal mice, which causes alteration of microenvironments of hematopoietic stem cells in the bone marrow and create a microenvironment for malignant cells followed by up-regulation of their growth by Janus kinase 2 (JAK2) and IL-6.