INS and obesity due to melanocortin 4 receptor deficiency: However, to investigate the relationship between colorectal carcinoma and MSG-induced obesity, Hata et al. [124] have also identified that MSG-induced obesity is at high risk for the development of azoxymethane-induced development of colon cancer via the up-regulation of IGF-1 receptor with an increased level of insulin, cholesterol and blood sugar respectively [124].