Hence, it can be suggested that HLD with a high amount of saturated fatty acids (e.g., palmitic acid, lauric acid, myristic acid), trans-fatty acids, hydrogenated fats activated LXRα-SREBP-1c pathway associated NAFLD, dyslipidemia, altered hepatic and cardiac metabolism, increased expression of certain pro-inflammatory factors, generation of ROS, a decrease of mitochondrial membrane potential (MMP) and necro-apoptosis in hepatocytes and cardiomyocytes respectively. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.