NFE2L2 and Glucose intolerance: Moreover, higher generation of 12-hydroxyeicosatetraenoic acid (12-HETE) occurred by the activation of the activity of 12-lipoxygenase in pancreatic β cells via the FFAs, cytokines, glucose intolerance by the consumption of HLD; this 12-HETE also an inducer of OS, which also inhibited the function of the nuclear factor erythroid 2-related factor 2 (Nrf2), ultimately leads to glucose intolerance and programmed cell death of β cells of the pancreas [184].