Furthermore, different isoforms of transforming growth factor-β (TGF-β) (e.g., TGF-β1, TGF-β2, and TGF-β3) promotes necroinflammation, development of hepatic fibrosis and steatohepatitis through Kupffer cells, stellate cells, and endothelial cells of the liver [190,191]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.