Massillo et al. [266​] proposed that high estradiol in serum contributed to fast growth of tumor in transgenic adenocarcinoma mouse prostate (TRAMP)-C1 allograft model via the up-regulation of transcription of cytochrome P450 aromatase (CYP19A) which further stimulated the conversion of androgen to estrogens; the transcription was regulated by intratumoral C-terminal-binding protein 1 (CtBP1) in lipids enriched diet received a murine model with rapid growth of neuroendocrine tumor model (e.g., TRAMP-C1 allograft tumor model) [266]. This evidence concerns the gene CTBP1 and neuroendocrine neoplasm.