A recent experiment was conducted to evaluate the underlying cause of the conversion of NASH to HCC, and the result suggests that long-term fat-enriched but choline-deficient diets developed NASH, and thereafter NASH mediated HCC; primarily a T cell-derived co-stimulatory ligand LIGHT secreted from the NKT cells, which, ultimately developed steatosis. This evidence concerns the gene TNFSF14 and metabolic dysfunction-associated steatohepatitis.