In addition, an ApoE−/− the murine model has been used to develop hyperlipidemia induced inflammatory responses on the progression of renal malfunction by the administration of HLD [161]; which further showed a significant up-regulation of pro-inflammatory factors like IL-6, TNF-α followed by the development of inflammation in kidney, the proliferation of mesangial cells and hyperalbuminemia. The gene discussed is IL6; the disease is hyperlipidemia.