Several risk factors for cryptococcosis have already been identified in SOTR: an older age, social precarity, underlying comorbidities (diabetes mellitus, HIV-infection), but also the type of immunosuppressive regimen (induction therapy with alemtuzumab [anti-CD52] or anti-thymocyte globulin, maintenance treatment with corticosteroids) [5]. This evidence concerns the gene CD52 and diabetes mellitus.