Recent publications have demonstrated that the Pip4k2c N‐terminus motif interacts with and suppresses Pip5k1α, thereby hindering phospho‐AKT in a prostate cancer cell line.[16, 41] Furthermore, inhibiting phosphorylated phospho‐AKT decreases Smad3 phosphorylation on site Ser208 (Smad3‐Ser208); such phosphorylation is crucial for TGFβ1 expression and pro‐fibrotic activity.[42] We therefore wanted to evaluate if phospho‐AKT and phospho‐smad3 (208) play a role in inhibiting Pip4k2c on TGFβ1 in the heart. Here, PIP4K2C is linked to Familial prostate cancer.