This increased CM size positively correlated with upregulated classic markers of cardiac hypertrophy, such as atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) (Figure 2l,m) in hearts of KO‐Pip4k2c mice after TAC in comparison to WT TAC or sham‐operated mice. This evidence concerns the gene NPPB and cardiac hypertrophy.