showed that topical application of the TLR7/8 ligand imiquimod for the treatment of invasive cutaneous squamous cell carcinoma caused an increase in granzyme B+ CD8+ T cells and polarized the lymphoid and monocyte/macrophage populations to a more Th1 and M1 cytokine pattern, respectively.[59] These findings were further corroborated by Clark et al. The gene discussed is GZMB; the disease is cutaneous squamous cell carcinoma.