DKC1 and cancer: Dyskerin acts as an RNA‐guided pseudouridine synthase, catalyzing the isomerization of uridine (U) nucleosides to pseudouridine (Ψ) nucleosides in its target RNAs,[10, 11] which include ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs), mRNAs, snoRNAs, and long noncoding RNAs.[12, 13] In addition, recent reports showed that dysregulated expression of DKC1 in various human cancer types altered cancer cell growth or metastasis and is associated with patient prognosis.[14, 15, 16]