CNOT6 and Infertility: Cnot6/6l–/– male mice had normal reproductive function (Figure S1C, Supporting Information), whereas Cnot6/6l–/– female mice were infertile as CNOT6L is essential for maternal mRNA clearance during oocyte meiotic maturation.[18] We used an antibody that targets both CNOT6 and CNOT6L for western blots; the results indicated that CNOT6/6L was completely absent in Cnot6/6l–/– testicular lysates (Figure S1D, Supporting Information).