By week 20 (a period of time during which hyperglycemia have occurred in a significant proportion of untreated NOD mice, Figure 2A), percentage of splenic Tregs remained the highest in the Nap‐GdFdFdY group though not statistically significant (Figure 4C), implicating a period‐specific action of Nap‐GdFdFdY on peripheral Treg activation. The gene discussed is CTNNBL1; the disease is Hyperglycemia.