In particular, the so‐called “aromatic triplet,” i.e., FFY, is critically required for providing distinct structure environment and association with insulin receptors as demonstrated by genetic manipulation and amino acid replacement experiments.[18c] Moreover, mutations of either phenylalanines were found to be associated with glucose intolerance and hyperglycemia, emphasizing the importance of the two phenylalanines for insulin activity. This evidence concerns the gene INSR and Hyperglycemia.