VacA secreted by H. pylori is a pore‐forming toxin which impairs the epithelium by inducing autophagy.[62] LPS produced by Gram‐negative bacteria, as a typical activator of TLR‐4, promoted CRC development through TLR4/ MyD88/NF‐kB signal pathway.[32, 56, 91] Song et al. Here, TLR4 is linked to colorectal carcinoma.