CD8A and neoplasm: The engineered strain with a synchronized lysis circuit (SLC) could produce the quorum‐sensing molecule acylhomoserine lactone and express φX174E, the increase of which resulted in the intratumoral quorum lysis of E. coli and the release of CD47nb (Figure 10A).[212] By blocking CD47, this intelligent bacteriotherapy increased tumor‐antigen‐specific CD8+ T cells, stimulated the rapid regression of A20 tumors, and prevented metastasis in mice (Figure 10B,C).