Heavy drinking is linked with a significantly increased risk of morbidity and mortality.[17, 18] It has been proposed that alcohol inhibits T cell activation to suppress anti‐tumor immune response.[19, 20] On the other hand, high expression of PD‐L1 is known to be associated with CRC immune evasion and poor prognosis.[21] Here, we reported that alcohol induced PD‐L1 expression in CRC cells in vitro and in vivo (Figure 1) without altering its mRNA level (Figure S1, Supporting Information). Here, CD274 is linked to neoplasm.