SETDB1 and schizophrenia: Setdb1 mutations have been found in a few autistic patients, which suggests Setdb1 might be related to the pathogenesis of ASD.[51] In addition, some studies also reported the role of Setdb1 in mood regulation and the pathogenesis of schizophrenia.[52, 53] In the Open Field test, we noticed that Setdb1mGFAPCKO mice always walked around the edge of the box repeatedly (data not shown).