POU5F1 and cancer: For example, the expression level of HIF‐1 is stable only under hypoxia and hypoxia is able to switch on an EMT programme leading cancer cells to acquire a fibroblastoid‐like phenotype and to display a significantly increased invasive propensity.[50] Oct4 can activate LEF1/β‐catenin dependent WNT signaling pathway and induce EMT.[51]