EGF and cancer: Numerous evidence has clarified the importance of IL6/STAT3 signaling for cancer growth, metastasis, and maintenance of cancer stem cells.[38] A variety of cytokines like IL‐6, epidermal growth factor (EGF), interferon (IFN) could induce STAT3 Tyr705 phosphorylation, a hallmark of JAK‐induced activation of STAT3.