POM121 and Familial prostate cancer: ST6GAL2 has been demonstrated to be a proapoptotic gene, and was significantly hypermethylated in CIN3+ lesions to promote cervical cancer progression.[50] POM121, encoding a transmembrane nucleoporin, has been considered to play a key contributor in prostate cancer aggressiveness.[51] Commonly mutated POM121 had been found in Mucosal Melanoma,[52] and was related to worse clinical outcomes.